Phthalates and Developing Male Brains
Published: 31 October 2006
Category: Phthalates, Studies/Federal Regulations
According to the study, “A dose–response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): Non-monotonic dose–response and low dose effects on rat brain aromatase activity,” from the Journal of Toxicology (227: 185-192), “safety standards based on high dose experiments are invalid.”
According to the article, the findings show that “lower doses of the phthalate DEHP suppress the activity of a key enzyme for masculinization of the male brain of rats, aromatase, while higher doses increase the enzyme’s activity.” Further, findings from this study show impacts at “environmentally-relevant levels.”